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转化酶抑制剂雷米普利(Ramipril下简称Ram)在离体灌流家兔心脏减弱外源性去甲肾上腺素(NE)和心交感神经刺激所致心率(HR)、心肌收缩力(FC)及冠脉流量(CF)的变化;显著减少心交感神经刺激期间内源性NE的释放。结果表明Ram能抑制心交感神经的传导及交感递质的释放,推测其作用原理可能是Ram在心脏局部抑制血管紧张素Ⅱ(ANGⅡ)的生成,从而干扰肾上腺素能神经传导时这一促进性肽所介导的接通。
Inverted enzyme inhibitor ramipril (Ramipril referred to as Ram) in perfused rabbit heart weakened exogenous norepinephrine (NE) and cardiac sympathetic stimulation caused by heart rate (HR), myocardial contractility (FC) And coronary flow (CF) changes; significantly reduce the release of endogenous NE during cardiac sympathetic nerve stimulation. The results show that Ram can inhibit cardiac sympathetic nerve conduction and the release of sympathetic transmitters, suggesting that the role of Ram may be in the heart local inhibition of angiotensin Ⅱ (ANG Ⅱ) generation, thus interfering with adrenergic nerve conduction of this promotion Peptide-mediated switch-on.