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从作物－昆虫－杀虫药剂三者之间的有机关系讨论了害虫的化学防治与作物抗虫性的相互关系。植物体内的某些次生性物质常是抗虫性利用的重要机制之一，这些次生性物质可以诱导昆虫体内的解毒酶系，而该酶系又能降解化学防治施用的杀虫药剂，从而加强害虫的抗药性。具有抗药性的昆虫由于含有大量的解毒酶系，会使某些抗虫品种对该昆虫种群的抗性降低甚至丧失。此外，杀虫药剂还可通过改变作物本身的生理生化代谢过程、营养质量以及次生性物质的产生，进而影响昆虫与寄主植物以及与杀虫药剂之间的关系。
The relationship between pest chemical control and crop pest resistance is discussed from the organic relationship among crop-insect-insecticide. Some secondary substances in plants are often one of the important mechanisms for the use of insect resistance. These secondary substances can induce detoxification enzymes in insects that can degrade insecticide used in chemical control and thus strengthen Pest resistance. Resistant insects due to the large number of detoxification enzymes, will make some insect-resistant varieties of the insect population resistance decreased or even lost. In addition, insecticides can affect the relationship between insects and host plants and insecticides by altering the physiological and biochemical metabolic processes of the crop itself, the nutritional quality and the production of secondary substances.