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目的:研究冠心病与血脂异常的相关性。方法:选择冠脉造影检查确诊的冠心病患者302例(CHD组),门诊体检无心脑血管疾病的健康人群218例(健康对照组),收集所有研究对象相关资料,测定其血甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白-胆固醇(LDL)、高密度脂蛋白-胆固醇(HDL-C)含量,并进行对比分析。结果:与健康对照组比较,CHD组血TC[(4.03±0.97)mmol/L比(4.62±1.06)mmol/L]、LDL-C[(2.51±0.86)mmol/L比(3.76±1.07)mmol/L]水平明显升高(P均﹤0.01)。多因素Logistic回归分析显示,LDL-C水平升高是冠心病发生的独立危险因素(OR=2.608,95%CI=1.268-5.366;P=0.009)。结论:本研究人群冠心病患者TC、LDL-C水平显著高于健康对照组,LDL-C水平升高可能是发生冠心病的一个独立危险因素。
Objective: To study the correlation between coronary heart disease and dyslipidemia. Methods: A total of 302 CHD patients diagnosed by coronary angiography (CHD) and 218 healthy subjects without cardiovascular and cerebrovascular diseases (healthy control group) were selected and their data were collected. The triglyceride (TG), total cholesterol (TC), low density lipoprotein-cholesterol (LDL) and high density lipoprotein-cholesterol (HDL-C) were measured and compared. Results Compared with healthy controls, the levels of TC [(4.03 ± 0.97) mmol / L vs (2.51 ± 0.86) mmol / L vs (3.76 ± 1.07) mmol / L] were significantly increased (all P <0.01). Multivariate logistic regression analysis showed that elevated LDL-C was an independent risk factor for coronary heart disease (OR = 2.608, 95% CI = 1.268-5.366; P = 0.009). Conclusion: The levels of TC and LDL-C in patients with coronary heart disease in this study were significantly higher than those in healthy controls. Elevated LDL-C level may be an independent risk factor for coronary heart disease.