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目的比较综合降糖、降压、利尿联合低分子肝素和多巴胺与单纯综合降糖、降压、利尿治疗糖尿病肾病Ⅳ期患者的效果。方法将102例糖尿病肾病Ⅳ期患者随机分为治疗组和对照组,每组51例,两组疗程均为3～4周,对比分析。结果治疗组餐前血糖、餐后2h血糖比对照组明显下降(P<0.001);24h尿蛋白定量减少,平均体重减轻,自觉症状数目减少等指标明显优于对照组(P<0.01)。结论临床结果表明综合利尿降糖降压联合低分子肝素与多巴胺治疗糖尿病肾病Ⅳ期患者在减少蛋白尿、消除水肿、改善临床症状等方面优于单纯一般综合降糖、降压、利尿治疗。
Objective To compare the effects of combined hypoglycemic, antihypertensive and diuretic combination of low molecular weight heparin and dopamine with simple hypoglycemic, antihypertensive and diuretic treatment of stage Ⅳ diabetic nephropathy. Methods A total of 102 patients with stage Ⅳ diabetic nephropathy were randomly divided into treatment group and control group, with 51 cases in each group. The course of treatment was 3 to 4 weeks in both groups. Results The pre-prandial blood glucose and postprandial 2-hour postprandial blood glucose in the treatment group decreased significantly (P <0.001). The urinary protein excretion, the average body weight loss and the number of subjective symptoms in 24h after treatment were significantly better than those in the control group (P <0.01). Conclusion The clinical results show that combination of diuresis, blood pressure lowering blood pressure and low molecular weight heparin and dopamine in patients with stage Ⅳ of diabetic nephropathy is superior to simple general hypoglycemic, antihypertensive and diuretic treatments in reducing proteinuria, eliminating edema and improving clinical symptoms.