原发性高血压患者血清胰岛素、T_3和T_4改变及硝苯啶的干预影响

• 作 者: 季乃军 方宗桥 王成尧 吕利雄 孙国文
• 机 构: 浙江省丽水市医院心内科
• 出 处: 临床内科杂志
• 发表日期: 1994年05期
• 关键词: 原发性高血压 T_3 T_4 血清胰岛素 硝苯啶 平均收缩压 轻度高血压 高胰岛素血症 交感神经活性 胰岛β细胞

作者采用放射免疫法测定了５０例未经治疗的原发性高血压（ＥＨ）和４０例同期入院的非ＥＨ患者血清胰岛素（ＩＳ），Ｔ３、Ｔ４和血糖（ＢＳ）水平，发现ＥＨ组血清ＩＳ显著高于对照组，而Ｔ３、Ｔ４和ＢＳ无显著性差异，ＥＨ组中２５例经平均口服硝苯啶４．２个月后，血清ＩＳ显著下降，但Ｔ３、Ｔ４和ＢＳ无显著改变，且ＩＳ下降与Ｔ３、Ｔ４和ＢＳ的变化也无相关性。

The authors used radioimmunoassay to determine the levels of serum insulin (IS), T3, T4 and blood glucose (BS) in 50 untreated patients with essential hypertension (EH) and 40 patients with non-EH at the same period. EH serum IS was significantly higher than the control group, while T3, T4 and BS no significant difference in EH group 25 patients with average oral nifedipine 4.2 months after the serum IS decreased significantly, but T3, T4 and BS no significant change , And the decrease of IS had no correlation with the changes of T3, T4 and BS.