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目的探讨尿微量蛋白测定对早期诊断糖尿病肾病的临床意义。方法 2007年3月2009年10月收住2型糖尿病患者67例,其中尿常规尿蛋白阳性为观察1组,尿常规尿蛋白阴性为观察2组,并选择健康体检志愿者30例设为正常对照组进行对照。采用免疫散射比浊法测定mAlb水平,放射免疫测定法测定尿液α1-MG和β2-MG。结果观察1、2组mAlb,α1-MG和β2-MG均高于正常对照组(P<0.05),观察1组增高更显著,观察2组与正常对照组相近(P>0.05)。结论尿微量蛋白测定在早期诊断糖尿病肾病诊断中具有重要价值。
Objective To investigate the clinical significance of urine microalbumin in the early diagnosis of diabetic nephropathy. Methods March 2007 October 2009 admitted 67 patients with type 2 diabetes mellitus, urine routine proteinuria was observed in group 1, urinal routine urine protein was observed in 2 groups and 30 healthy volunteers were selected as normal Control group for control. The level of mAlb was determined by immunoturbidimetric method and the urine α1-MG and β2-MG were measured by radioimmunoassay. Results The levels of mAlb, α1-MG and β2-MG in group 1 and 2 were significantly higher than those in normal control group (P <0.05). The increase in group 1 was more significant than that in normal control group (P> 0.05). Conclusion The determination of urinary microalbumin is of great value in the early diagnosis of diabetic nephropathy.