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小儿原发性膀胱输尿管反流 (vesicouretericreflux ,VUR)与尿路感染、排尿功能障碍相伴发生常常导致肾疤痕、肾萎缩、高血压、肾功能减退等一系列反流性肾病的表现 ,重者甚至进展为终末期肾病。目前 ,从尿流动力学、血流动力学、感染、免疫及遗传学等多领域探索VUR及反流性肾病的发病机制。VUR的诊断技术在影像、生化、尿流动力学等多领域有很大进展 ,提高了对反流及肾损害的评价敏感性。小儿原发性VUR需要及早诊断 ,同时对肾损害做出充分的预测 ,建立个体化的有效的治疗方案
In children with primary urinary vesicoureteral reflux (vesicouretericreflux, VUR) and urinary tract infections, urinary dysfunction, often accompanied by a series of renal scarring, renal atrophy, hypertension, renal dysfunction and a series of performance of reflux disease, severe or even Progress to end-stage renal disease. Currently, the pathogenesis of VUR and reflux nephropathy is explored from the aspects of urodynamics, hemodynamics, infection, immunity and genetics. VUR diagnostic techniques in the field of imaging, biochemistry, urodynamics and other fields have made great progress, improve the evaluation of reflux and renal damage sensitivity. Children with primary VUR need early diagnosis, while adequate prediction of renal damage, the establishment of individualized and effective treatment programs