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目的 观察模拟失重大鼠腰椎骨骨质和生物力学特性在恢复期的变化。 方法 选用7周龄雄性 Wistar大鼠 ,随机分为 6组 ,1组尾吊 2 1d;1组尾吊 2 1d后解悬 7d;1组尾吊 2 1d后解悬 2 1d;其余 3组为对照组。实验结束后测定第三腰椎骨 (L3)的矿盐含量、骨钙素浓度及生物力学指标。 结果 大鼠 L3矿盐含量、载荷能力、应力水平、强度及硬度等在尾吊 2 1d均有非常显著性意义的降低 (P <0 .0 1) ,解悬 7d后未见明显变化 ,解悬 2 1d后有恢复的趋势 ,但仍显著低于对照水平(P<0 .0 1) ;骨钙素含量在整个实验过程中均显著低于对照水平 (P<0 .0 5 ) ;横截面积在尾吊后下降有显著性意义 (P<0 .0 1) ,但解悬 2 1d已恢复至正常对照水平。 结论 模拟失重致大鼠 L3矿盐含量及生物力学性能下降 ,且在短时间内不易恢复
Objective To observe the changes of lumbar vertebra bone mass and biomechanical properties during convalescence in simulated weightlessness rats. Methods Male Wistar rats, 7 weeks old, were randomly divided into 6 groups, 1 tail tail hanging for 21 days, 1 tail tail hanging for 2 days and 7 days post-tail suspension, 1 tail tail hanging for 21 days, Control group. After the experiment, the third lumbar spine (L3) mineral salt content, osteocalcin concentration and biomechanical parameters were measured. Results The content of mineral salt, loading capacity, stress level, strength and hardness of L3 in tail suspension were significantly decreased on the 21st day (P <0. 01), and no significant changes were observed after 7 days of suspension (P <0.01). Osteocalcin content was significantly lower than that of the control (P <0.05) in the whole experiment; horizontal The cross-sectional area decreased after the tail suspension (P <0.01), but the solution suspended 21 days had returned to normal control level. Conclusion The salt content and biomechanical properties of L3 in rats after simulated weightlessness decrease, and it is not easy to recover in a short time