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目的回顾洋葱伯克霍尔德菌(Burkholderid depacia,BC)的分离与药敏结果,为院内感染洋葱伯克霍尔德菌的治疗提供可靠的依据。方法用微量稀释法测定14种抗生素对79株洋葱伯克霍德菌的最低抑菌浓度(M IC),并对菌株来源及不同科室检出株的药敏结果进行分析。结果该菌检出率为2.48%,从各种临床标本中共分离到洋葱伯克霍尔德菌79株,以下呼吸道标本为主占75.95%,其次为血液标本占16.46%;洋葱伯克霍尔德菌对9种抗菌药物耐药率超过60%,对亚胺培南的敏感率低于30.77%,对哌拉西林/他唑巴坦和复方新诺明敏感。来自ICU的洋葱伯克霍尔德菌耐药更强。结论洋葱伯克霍尔德菌耐药及多药耐药性严重,应引起广泛关注,尤其是中心ICU,治疗上可选用哌拉西林/他唑巴坦。
Objective To review the isolation and drug susceptibility of Burkholderid depacia (BC), and provide a reliable basis for the treatment of Burkholderia cepacia in hospital. Methods The minimum inhibitory concentration (M IC) of 14 antibiotics on 79 Burkholderia cepacia was determined by microdilution method. The drug susceptibility results of strains and strains detected in different departments were analyzed. Results The detection rate of this bacterium was 2.48%. 79 Burkholderia cepacia were isolated from various clinical samples. The following respiratory specimens accounted for 75.95%, followed by blood samples accounted for 16.46% The rate of resistance to nine antibacterials was more than 60% and the susceptibility to imipenem was less than 30.77%, which was sensitive to piperacillin / tazobactam and cotrimoxazole. Burkholderia cepacia from the ICU is more resistant. Conclusion Burkholderia cepacia is resistant to multidrug-resistant and multidrug-resistant, which should be paid more attention, especially in the central ICU. Piperacillin / tazobactam may be used therapeutically.