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21岁和11岁两位患者患严重的持续性盾形溃疡,包括局部激素、肥大细胞稳定剂及抗组胺药的药物治疗均无效。两者均接受溃疡的外科清创,上睑板下注射曲安奈德,局部用0.5g/L环孢霉素A和0.25g/L富马酸酮替芬治疗。3wk后溃疡愈合。2mo后两位患者停用局部环孢霉素A。患者症状缓解,6mo没有复发。联合溃疡的外科清创,上睑板下注射曲安奈德,局部用0.5g/L环孢霉素A和0.25g/L富马酸酮替芬是治疗重度春季盾形溃疡的有效方案。
Both 21-year and 11-year-old patients had severe persistent herpetic ulcers, including those with topical hormones, mast cell stabilizers, and antihistamines. Both received surgical debridement of the ulcer, triamcinolone acetonide injection under the tarsal plate topical treatment with 0.5 g / L cyclosporin A and 0.25 g / L ketotifen fumarate. 3wk ulcer healing. Two patients discontinued partial cyclosporine A after 2 months. Patients with symptoms, 6mo no recurrence. Surgical debridement combined with ulceration, triamcinolone acetonide injection under topral parenteral topical administration of 0.5 g / L cyclosporine A and 0.25 g / L ketotifen fumarate are effective regimens for the treatment of severe spring ulcers.