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目的探讨伴微乳头状分化的胃肠道腺癌的临床病理学特征。方法选择2009年1月至2012年12月收治的伴微乳头状分化的胃肠道腺癌50例作为观察组,同期选择普通胃肠道原发腺癌50例作为对照组,观察两组患者的临床病理特征,同时进行EMA、E-Cadherin和IMP3的免疫组织化学分析。结果观察组患者的肿瘤浸润程度和临床分期均显著高于对照组,差异有统计学意义(P<0.05)。观察组患者的EMA表达阳性率为56.0%,对照组患者的EMA表达阳性率为24.0%,差异有统计学意义(P<0.05)。观察组患者的IMP3表达水平高于对照组,而E-cadherin表达水平则明显下降,差异有统计学意义(P<0.05)。结论伴微乳头状分化的胃肠道腺癌具有高侵袭性与高分期的临床特征,可造成EMA和IMP3表达率增加以及E-cadherin表达率降低,提示其有特殊的增殖活性和细胞黏附性。
Objective To investigate the clinicopathological features of gastrointestinal adenocarcinoma with micro-papillary differentiation. Methods 50 cases of gastrointestinal adenocarcinoma with micropapillary differentiation admitted from January 2009 to December 2012 were selected as observation group and 50 cases of primary gastrointestinal adenocarcinoma were selected as control group in the same period. The clinicopathological features of EMA, E-Cadherin and IMP3 were also examined by immunohistochemistry. Results The degree of tumor infiltration and clinical stage of observation group were significantly higher than that of control group, the difference was statistically significant (P <0.05). The positive rate of EMA expression in the observation group was 56.0%, while the positive rate of EMA expression in the control group was 24.0%, the difference was statistically significant (P <0.05). The expression level of IMP3 in the observation group was higher than that in the control group, while the expression of E-cadherin was significantly decreased (P <0.05). Conclusion The clinical features of high invasive and high-staging adenocarcinoma with micro-papillary differentiation may lead to the increase of EMA and IMP3 expression and the decrease of E-cadherin expression, suggesting that it has special proliferative activity and cell adhesion .