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著名的英国学者Medawar在20世纪五十年代提出妊娠期哺乳动物胚胎与其母体的免疫学关系相当于同种异基因移植物与其受者的关系。妊娠期母体免疫系统对胚移植抗原的免疫耐受是母胎间免疫调节达到平衡状态的结果,这种免疫平衡状态的维持涉及诸多因素:如胎盘主要组织相容性复合体(m
The famous British scholar Medawar proposed in the 1950s that the immunological relationship between a pregnant mammalian embryo and its mother corresponds to the allograft’s relationship with its recipient. Immune tolerance of the maternal immune system to the embryo transfer antigen during pregnancy is the result of a balance of immunomodulatory status between maternal and fetal fetuses, and maintenance of this immune balance involves a number of factors such as the placental major histocompatibility complex (m