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目的 探讨肠外营养对新生儿短肠综合征 (SBS)患儿治疗的作用。方法 回顾总结1988～ 2 0 0 1年在我院PN支持治疗的 9例新生儿短肠综合征 ,观察PN开始时对患儿生长的影响及PN相关并发症。结果 9例长期随访中 8例存活 ,1例放弃治疗后死亡。4例出现并发症 ,严重低钙1例 ,血尿、右肾结石 1例 ,胆汁淤积 1例 ,贫血 1例 ,经治疗后痊愈。PN开始迟的 2例 ,第 1个月体重下降明显。PN开始早的 7例 ,3例伴CMV感染者生后 3个月内体重增加较非感染组缓慢 ,两组比较有显著性差异 (t=5 .78,P =0 .0 0 2 )。结论 SBS患儿应早期营养支持。SBS患儿伴CMV感染将严重影响体重增加。SBS患儿PN治疗期间并发症出现率较高 ,应予高度重视。
Objective To investigate the effect of parenteral nutrition on the treatment of neonates with short bowel syndrome (SBS). Methods Nine cases of neonatal short bowel syndrome treated with PN support during our hospital from 1988 to 2001 were retrospectively reviewed. The effects of PN on the growth of children and PN related complications were observed. Results Nine patients survived in long-term follow-up, and one died after giving up treatment. 4 cases of complications, severe low calcium in 1 case, hematuria, right kidney stone in 1 case, cholestasis in 1 case, anemia in 1 case, cured after treatment. 2 patients started PN late, the first month of weight loss significantly. In the 7 patients with early onset of PN, the body weight gain of 3 patients with CMV infection within 3 months after birth was slower than that of non-infected patients. There was significant difference between the two groups (t = 5.78, P = 0.002). Conclusion SBS children should be early nutritional support. SBS children with CMV infection will seriously affect the weight gain. The incidence of complications during PN treatment in SBS children should be given high priority.