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目的了解手足口病的病原学特征,为手足口病的诊断提供科学依据。方法采用RT-PCR方法对2008年龙岩市手足口病患者及其密切接触者616人的893份标本进行EV71和COXA16检测。结果检测患者及其密切接触者616人,EV71阳性率为18.01%,COXA16阳性率为4.55%;检测标本893份,EV71阳性率为20.94%,COXA16阳性率为5.82%。咽拭、粪便(肛拭)、疱疹液EV71阳性率分别为22.69%、19.63%、16.13%(P>0.05),COXA16阳性率分别为4.19%、6.37%、14.52%(P<0.01)。结论2008年从手足口病患者及其密切接触者的咽拭、粪便(肛拭)、疱疹液中检出EV71和COXA16。
Objective To understand the etiological characteristics of HFMD and provide a scientific basis for the diagnosis of HFMD. Methods RT-PCR was used to detect EV71 and COXA16 in 893 specimens of 616 people with HFMD in Longyan City in 2008 and their close contacts. Results There were 616 patients and their close contacts. The positive rate of EV71 was 18.01% and the positive rate of COXA16 was 4.55%. The positive rate of EV71 was 20.94% and the positive rate of COXA16 was 5.82%. The positive rates of EV71 in pharyngeal swab, feces (anal swab) and herpes fluid were 22.69%, 19.63% and 16.13% respectively (P> 0.05). The positive rates of COXA16 were 4.19%, 6.37% and 14.52% (P <0.01). Conclusion In 2008, EV71 and COXA16 were detected in throat swabs, feces (anal swabs) and herpes fluid of HFMD patients and their close contacts.