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多巴胺(DA)在肠道和肝脏中具有显著的首过代谢作用。为降低多巴胺的强首过代谢,作者合成了一种多巴胺前药N-(N-乙酰基-L-蛋氨酰)-O,O-二乙氧羰基多巴胺(1),保护了在DA 分子中起钝化代谢作用的两个主要部位(氨基和儿茶酚结构)。本研究
Dopamine (DA) has significant first-pass metabolism in the gut and liver. To reduce the strong first-pass metabolism of dopamine, the authors synthesized a dopamine prodrug N- (N-acetyl-L-methionyl) -O, O-diethoxycarbonyl dopamine (1) The two main parts of passivation metabolism (amino and catechol structures). this research