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目的比较辅助生殖技术中玻璃化和程序化2种冷冻方法对卵裂期胚胎的冷冻复苏效果及临床结局。方法对3396个玻璃化冷冻周期和685个程序化冷冻周期的相关资料进行回顾性统计学分析,比较解冻后胚胎复苏率、优质胚胎率、临床妊娠率和胚胎着床率等指标。结果玻璃化冷冻后的胚胎复苏率、优质胚胎率、临床妊娠率和胚胎着床率均显著高于程序化冷冻,且复苏周期移植取消率显著低于程序化冷冻。结论相对于程序化冷冻法,玻璃化冷冻法具有更好的冷冻复苏效果以及临床结局,更适用于卵裂期胚胎的冷冻保存。
Objective To compare the effects of two methods of vitrification and programmed cryopreservation on the cryopreservation and clinical outcome of cleavage stage embryos in assisted reproductive technology. Methods The data of 3396 vitrification cycles and 685 programmed freezing cycles were retrospectively analyzed. The indexes of thawed embryo recovery rate, high quality embryo rate, clinical pregnancy rate and embryo implantation rate were compared. Results After vitrification, embryo recovery rate, high quality embryo rate, clinical pregnancy rate and embryo implantation rate were significantly higher than those of programmed freezing, and the abolition rate of resuscitation cycle was significantly lower than that of programmed freezing. Conclusion Compared with the programmed freezing method, vitrification has better freezing and resuscitation effects and clinical outcomes, more suitable for cryopreservation of cleavage stage embryos.