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目的比较诺氟沙星栓剂（Ａ组）与注射液（Ｂ组）在治疗妇科炎性疾病中的疗效。方法采用诺氟沙星阴道栓剂及注射液治疗妇科炎性疾病各５０例，于用药前及用药后２ｈ、４ｈ取静脉血测血药浓度。治疗的第５天及第１０天做阴道分泌物涂片，个别作培养。查分泌物及血尿常规，并作妇科检查，盆腔有包块者行Ｂ超检查，观察疗效。结果用药后２ｈ测静脉血药浓度Ａ组１６．６μｇ／ｍｌ，Ｂ组１８．９μｇ／ｍｌ。明显高于口服给药的血药浓度０．７８μｇ／ｍｌ。两组治愈例数Ａ组４５例（９０％），Ｂ组４７例占９４％（Ｐ＞０．０５），疗效无显著差异。结论诺氟沙星栓剂及注射液治疗妇科炎症性疾病均有效。
Objective To compare the efficacy of norfloxacin suppository (group A) and injection (group B) in the treatment of gynecological inflammatory diseases. Methods Norfloxacin vaginal suppository and injection for the treatment of 50 cases of gynecological inflammatory diseases, before and after treatment 2h, 4h venous blood concentration. Vaginal secretions were smeared on day 5 and day 10 of treatment and were individually cultured. Check secretions and hematuria routine, and for gynecological examination, pelvic mass who line B-ultrasound, observe the effect. Results 2h after treatment, the measured plasma concentration of A group 16.6μg / ml, B group 18.9μg / ml. Significantly higher than the oral administration of plasma concentration of 0.78μg / ml. There were 45 cases (90%) in group A and 47 cases in group B, accounting for 94% (P> 0.05). There was no significant difference between the two groups. Conclusion Norfloxacin suppository and injection for the treatment of gynecological inflammatory diseases are effective.