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目的:探讨急性动脉粥样硬化性脑梗死(acute atherosclerotic cerebral infarction,AACI)患者血清亲环素A水平变化的临床意义。方法:选取2013年4月至2014年4月48例AACI患者为观察组,再选择48例健康人群作为对照组。检测两组血清亲环素A、基质金属蛋白酶-9(MMP-9)以及超敏C反应蛋白(hs-CRP)水平,并对检测结果进行对比。结果:观察组血清亲环素A、MMP-9以及hs-CRP水平均显著高于对照组,差异均有统计学意义(P<0.05)。两组血压、甘油三酯以及血糖等指标比较,差异均无统计学意义(P>0.05);观察组血浆结缔组织生长因子(CTGF)水平和不同斑块检出情况所对应血清亲环素A、MMP-9、hsCRP水平间比较,差异均无统计学意义(P>0.05);观察组血清亲环素A水平与MMP-9、Hs-CRP水平呈正相关,与血浆CTGF水平以及斑块检出情况无明显相关性。结论:检测血清亲环素A质量浓度,有利于掌握AACI患者病情,对该病的预防和诊治具有重要意义,值得推荐。
Objective: To investigate the clinical significance of serum cyclophilin A level in patients with acute atherosclerotic cerebral infarction (AACI). Methods: Forty-eight patients with AACI from April 2013 to April 2014 were selected as observation group and 48 healthy people as control group. Serum levels of cyclophilin A, MMP-9 and hs-CRP were measured in both groups, and the results were compared. Results: The levels of serum cyclophilin A, MMP-9 and hs-CRP in the observation group were significantly higher than those in the control group, with statistical significance (P <0.05). Blood pressure, triglyceride and blood glucose and other indicators of the two groups showed no significant difference (P> 0.05); the level of plasma connective tissue growth factor (CTGF) in the observation group and the detection of different plaques of serum cyclophilin A , MMP-9 and hsCRP were not significantly different between the two groups (P> 0.05). The level of serum cyclophilin A in the observation group was positively correlated with the level of MMP-9 and Hs-CRP, No significant correlation between the situation. Conclusion: The detection of serum cyclophilin A concentration is conducive to mastering the condition of patients with AACI, which is of great significance for the prevention and diagnosis of the disease and is worth recommending.