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氮氟灭酸(Niflumic acid,商品名Nifluril)是一种烟酸衍生物。作为非甾体抗炎药,在广泛应用中已证明有强而稳定的止痛、抗炎作用。易从肠胃道吸收,口服后约2 h血浆中达峰浓度;还有消除半衰期较短的优点(3h左右)。尽管主要由肾排泄,但不受肾功能衰竭或年龄增大的影响。氮氟灭酸的作用为抑制前列腺素的合成,从而能有效地抑制局部或全身性炎症。近来研究表明,氮氟灭酸的作用包括兴奋巨噬细胞、增强抗体反应和抑制前列腺素合成。
Niflumic acid (Nifluril) is a niacin derivative. As a non-steroidal anti-inflammatory drugs, in a wide range of applications have been shown to have strong and stable analgesic, anti-inflammatory effect. Easily absorbed from the gastrointestinal tract, about 2 h after oral administration of plasma peak concentration; also eliminate the advantages of shorter half-life (3h or so). Although mainly excreted by the kidneys, it is not affected by renal failure or age. Nitrofluoromethionine inhibits the synthesis of prostaglandins, which can effectively suppress local or systemic inflammation. Recent studies have shown that the role of flufenamic acid, including excitatory macrophages, enhance antibody responses and inhibit prostaglandin synthesis.