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目的：分析安徽地区儿童感染耐甲氧西林葡萄球菌（MRS）的耐药情况。方法采用PCR扩增mecA方法收集M RS菌株，对安徽地区2010年‐2014年临床分离的儿童感染M RS进行药敏试验。结果共收集MRS184株；其中，耐甲氧西林金黄色葡萄球菌36株，耐甲氧西林凝固酶阴性葡萄球菌（MRCNS）148株。耐药分析显示，所有M RS均对亚胺培南、美罗培南、替考拉宁、万古霉素较为敏感，耐药率均在20％以下；对其他12种临床常见抗菌药物表现出不同程度的耐药性。检出1株携带mecA基因的万古霉素表型耐药的耐甲氧西林表皮葡萄球菌。结论安徽地区临床分离的儿童M RS具有多重耐药性，出现万古霉素表型耐药M RC N S菌株，应予警惕。“,”Objective To analyze the drug resistance of methicillin resistant Staphylococcus (MRS) in children in Anhui area .Methods With PCR mecA gene detection method ,the MRS strains were collected between 2010 and 2014 from children in Anhui and the susceptibility testing was performed .Results A total of 184 MRS strains was detected ,of which MRSA accounted for 36 strains and MRCNS for 148 strains .The antibiotic resistance analysis showed that all MRS strains were more sensitive to the imipenem ,meropenem ,teicoplanin and vancomycin . The antibiotic resistance rates were below 20% .However ,all MRS strains showed different degrees of resistance to the other 12 kinds of clinical common antibacterial drugs .One strain of MRSE carring mecA gene was checked out .Conclusion Clinical strain of MRS isolated from children in Anhui has multiple resistances to commonly used antibiotics .Attention should be paid to the appearance of vancomycin phenotypic drug resistant strain of MRCNS in Anhui .