论文部分内容阅读
采用改良的Eriksson法。分析55例麻风(TT型15例,界线类30例,LL型10例)及60例健康人血清中的α_1抗胰蛋白酶抑制活力(α_1—AT)。结果TT型的α_1—AT为1.18±0.15mg/ml,同正常人比较差异不显著(p>0.05);界线类为1.02±0.28mg/ml,同正常人比较差异非常显著(p>0.01);LL型为0.78±0.42mg/ml,也明显低于正常人(p<0.01)。α_1—AT均值从TT端移行至LL端时呈逐渐下降趋势。α_1—AT缺乏在麻风的发病中可能起一定作用。推测用纯化的α_1—AT或提高α_1—AT产生的制剂可能对麻风的治疗有益。
Using a modified Eriksson method. The α_1 antitrypsin inhibitory activity (α_1 -AT) in 55 leprosy patients (15 TT patients, 30 borderline patients, 10 LL patients) and 60 healthy volunteers was analyzed. Results The α_1-AT of TT type was 1.18 ± 0.15mg / ml, which was not significantly different from that of normal subjects (p> 0.05). The borderline class was 1.02 ± 0.28mg / ml, which was significantly different from that of normal subjects (p> 0.01) ; LL type was 0.78 ± 0.42mg / ml, also significantly lower than normal (p <0.01). The mean value of α_1-AT showed a gradual downward trend from the TT end to the LL end. α_1-AT deficiency may play a role in the pathogenesis of leprosy. It is speculated that treatment with leprosy may be beneficial with either purified [alpha] l-AT or agents that increase [alpha] l-AT production.