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目的探讨抗心磷脂抗体(ACA)与癫痫发病的关系。方法采用ELISA法对50例癫痫患者和50例正常对照者的血清ACA进行测定比较。结果癫痫组患者用药前ACA阳性36例,阳性率为72%;正常对照组ACA阳性2例,阳性率为4%。经统计学处理,癫痫组患者用药前ACA阳性率明显高于对照组,差异具有显著性(P<0.01)。结论癫痫患者存在自身免疫功能的紊乱,ACA与癫痫发病有着密切关系,血清ACA可作为癫痫的辅助诊断指标用于临床。
Objective To investigate the relationship between anti-cardiolipin antibody (ACA) and epilepsy. Methods Serum ACA levels in 50 patients with epilepsy and 50 normal controls were measured by ELISA. Results In the epilepsy group, 36 cases were positive for ACA before treatment, the positive rate was 72%. In the normal control group, 2 cases were positive for ACA, the positive rate was 4%. Statistically, the positive rate of ACA in patients with epilepsy before treatment was significantly higher than that of the control group, the difference was significant (P <0.01). Conclusions The existence of autoimmune disorders in patients with epilepsy, ACA and epilepsy have a close relationship, serum ACA can be used as a secondary diagnostic indicator of epilepsy in clinical.