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目的以胸片为主要观察指标,从不同介入治疗的时点,对中西医结合治疗SARS肺部炎症的临床疗效进行客观评价,为更好地把握中医药治疗SARS用药时机提出科学依据。方法采用多中心前瞻性队列研究的方法,通过对参加国家“863”重大项目“中西医结合治疗SARS临床研究”的北京地区11家医院,361例确诊SARS患者的1561张胸片的研究,阐明不同时点中西医结合治疗对SARS肺部炎症的影响。结果在发病1~7d内中西医结合早期治疗组,SARS肺部炎症吸收的疗效明显优于西医组,特别是对重型患者的效果具有统计学差异。结论中西医结合早期干预对SARS肺部炎症吸收的临床疗效具有明显的优势。
OBJECTIVE To evaluate the clinical efficacy of integrated traditional Chinese and western medicine in the treatment of SARS-induced lung inflammation from the perspective of different interventions and to provide a scientific basis for better understanding the timing of traditional Chinese medicine (TCM) treatment of SARS. METHODS: A multicenter prospective cohort study was conducted to investigate the effect of 1561 chest radiographs on 11 hospitals in Beijing and 361 patients with confirmed SARS who participated in the national “863” major project “SARS Clinical Study” Effect of Traditional Chinese Medicine Combined with Western Medicine on Pulmonary Inflammation in SARS at Different Times. Results In the early stage of the treatment of Integrative Chinese and Western Medicine within 1 ~ 7 days of onset, the efficacy of lung inflammation absorption in SARS was significantly better than that in Western medicine group, especially for severe patients. Conclusion The clinical efficacy of early intervention with integrated traditional Chinese and western medicine on SARS pulmonary inflammation has obvious advantages.