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目的 :探讨影响声门上型喉癌颈淋巴结转移的临床病理因素及颈淋巴结转移对预后的影响。方法 :用 χ2 检验和Logistic回归分析 ,对 5 5例声门上型喉癌患者的肿瘤临床病理学因素与颈淋巴结转移的关系进行回顾性分析 ;并对颈淋巴结转移状态 ,转移颈淋巴结大小、数目、累及区域、最低受累区域等病理学因素对预后的影响进行Cox回归分析。结果 :单因素分析显示 ,肿瘤病理分级、肿瘤大小、肿瘤浸润深度与发生颈淋巴结转移有关 ;多因素分析显示 ,肿瘤病理分级、肿瘤大小与发生颈淋巴结转移明显相关 ;声门上型喉癌患者 5年生存率为5 2 .7%。Cox回归分析表明 ,临床N分期、颈淋巴结转移状态、转移颈淋巴结大小影响患者预后。结论 :声门上型喉癌颈淋巴结转移的发生受原发癌病理学因素的影响 ,它从多个角度明显影响患者预后 ;对影响预后的淋巴结因素采取相应治疗措施 ,对提高声门上型喉癌的治疗效果具有重要意义。
Objective: To investigate the clinicopathological factors affecting the metastasis of cervical lymph nodes and the effect of cervical lymph node metastasis on the prognosis of supraglottic laryngeal carcinoma. Methods: Chi-square test and logistic regression analysis were used to analyze the relationship between clinicopathological parameters and cervical lymph node metastasis in 55 cases of supraglottic cancer; and to analyze the relationship between cervical lymph node metastasis, Cox regression analysis was used to analyze the influence of pathological factors such as number, involved area, lowest involved area and prognosis. Results: Univariate analysis showed that tumor pathological grade, tumor size and depth of tumor invasion correlated with the occurrence of cervical lymph node metastasis. Multivariate analysis showed that tumor pathological grade and tumor size were significantly correlated with cervical lymph node metastasis. In patients with supraglottic laryngeal cancer The 5-year survival rate was 52.2%. Cox regression analysis showed that the clinical stage N, cervical lymph node metastasis, metastatic cervical lymph node size affect the prognosis of patients. Conclusions: The incidence of cervical lymph node metastasis of supraglottic laryngeal carcinoma is affected by the pathological factors of primary cancer. It can significantly affect the prognosis of patients with supraglottic laryngeal cancer. The treatment of lymph node factors that affect prognosis should be taken to improve the supraglottic The therapeutic effect of laryngeal cancer is of great significance.