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骨肉瘤是最常见的骨恶性肿瘤,但其发生机制目前尚未阐明。而核转录因子Snail不仅参与与骨肉瘤复发转移及预后有关的上皮细胞间质化过程,而且在肿瘤干细胞特性产生和维持、细胞生存和凋亡以及免疫调节中起着重要的作用,其有望成为骨肉瘤等恶性肿瘤治疗的一个新靶点。
Osteosarcoma is the most common bone malignancy, but its mechanism has not yet been elucidated. The nuclear transcription factor Snail is not only involved in the process of epithelial cell interstitialization related to the recurrence, metastasis and prognosis of osteosarcoma, but also plays an important role in the generation and maintenance of tumor stem cell characteristics, cell survival and apoptosis, and immune regulation, which is expected to become Osteosarcoma and other malignant tumors a new target.