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目的:评价α-硫辛酸治疗2型糖尿病周围神经病变的有效性。方法:将2011年至2012年我院收治2型糖尿病周围神经病变患者共64例随机分为试验组(n=32)和对照组(n=32),其中试验组使用α-硫辛酸治疗,对照组使用谷胱甘肽治疗,治疗前后对其进行TSS。结果:试验组患者应用α-硫辛酸治疗后,TSS较治疗前改善4.37分(P<0.01),且未见明显不良反应。结论:α-硫辛酸相对于谷胱甘肽可明显改善2型糖尿病患者周围神经病变的症状,且无明显不良反应。
Objective: To evaluate the effectiveness of α-lipoic acid in the treatment of type 2 diabetic peripheral neuropathy. Methods: A total of 64 patients with type 2 diabetic peripheral neuropathy in our hospital from 2011 to 2012 were randomly divided into experimental group (n = 32) and control group (n = 32), in which the experimental group was treated with α-lipoic acid, The control group was treated with glutathione and TSS was administered before and after treatment. Results: After treatment with α-lipoic acid, the TSS improved 4.37 points (P <0.01) before treatment, and no obvious adverse reactions were observed. Conclusion: α-lipoic acid relative to glutathione can significantly improve the symptoms of peripheral neuropathy in patients with type 2 diabetes mellitus, and no obvious adverse reactions.