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The generalized conditionalsymmetry and sign-invariant approaches are developed to study the nonlinear diffusion equations with x-dependent convection and source terms. We obtain conditions under which the equations admit the second-order generalized conditional symmetries and the first-order sign-invariants on the solutions. Several types of different generalized conditional symmetries and first-order sign-invariants for the equations with diffusion of power law are obtained. Exact solutions to the resulting equations are constructed.