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目的：探讨熊去氧胆酸（UDCA）联合多烯磷脂酰胆碱（PPC）治疗胆囊结石的临床疗效。方法：选取承德市中心医院2014年9月至2016年3月收治的100例胆囊结石合并胆总管结石患者为研究对象。随机分为观察组与对照组各50例。两组病例均成功行逆行ERCP+ EST+胆总管取石术；观察组术后口服UDCA联合PPC，对照组术后仅口服UDCA。随访、复查后统计胆囊结石溶解情况、胆囊壁厚度、胆囊收缩率。结果：观察组与对照组胆囊结石溶解有效率有显著差异（p<0.05）。观察组与对照组胆囊壁厚度、胆囊收缩功能均与治疗前有显著差异（p0.05）。结论：熊去氧胆酸联合多烯磷脂酰胆碱治疗胆囊结石疗效显著，并且能较好地改善胆囊炎症及胆囊收缩功能。“,”Objective: To investigate clinical efficacy of Ursodeoxycholic acid and Polyene Phosphatidylcholine in treating of galstones. Methods:one hundred patients with galbladder and bile duct stones treated were randomly divided them into either an observation group or a control group.two groups of cases were successful line of the endoscopic sphincterotomy. After ,Twogrouprespectivelytook UDCA + PPCandUDCA. Folowed upandchecked with B-type ultrasonic inspection to assess the galbladder stones dissolved and thickness of galbladder and galbladder shrinkage.Results:After 6 months, both groups’ efficacy of resolving-stones wassignificant difference(p < 0.05).Two group after treatment of galbladder wal thickness and galbladder contraction function were significantly difference(p 0.05).Conclusion:The clinical efficiency of UDCAand PPC in treating of galstones is distinct.