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目的:探讨左旋氨氯地平联合综合性心理干预治疗高血压伴围绝经综合征患者的临床治疗效果,为临床治疗提供参考。方法:按照随机数字表法将2014年7月-2015年7月三峡大学仁和医院收治的113例高血压伴围绝经综合征患者分为两组,观察组(n=57例)采用左旋氨氯地平联合综合性心理干预,对照组(n=56例)仅予以左旋氨氯地平治疗。治疗1个月后,采用汉密尔顿焦虑量表(HAMA)和抑郁量表(HAMD)评分对两组患者的主要症状改善进行评估,测量两组治疗前后卵巢功能指标促黄体生成素(Luteinizing hormone,LH)、血清促卵泡成熟激素(Follicle stimulating hormone,FSH)以及雌激素(Estrogen,E2),并比较两组患者治疗后的临床疗效。结果:两组患者治疗后的LH、FSH以及E2水平均较治疗前明显改善,且观察组改善的幅度明显优于对照组,差异有统计学意义(P<0.05)。两组治疗后的HAMA、HAMD评分均较治疗前降低,且观察组降低的幅度明显优于对照组,差异有统计学意义(P<0.05)。观察组治疗后的临床疗效优于对照组,差异有统计学意义(P<0.05)。结论:左旋氨氯地平联合综合性心理干预可明显改善患者的负性情绪和提高临床治疗效果,有较高的临床推广价值。
Objective: To investigate the clinical effect of combined treatment of levamlodipine and comprehensive psychotherapy on patients with hypertension and menopausal syndrome and to provide reference for clinical treatment. Methods: According to the random number table method, 113 cases of hypertensive menopausal syndrome patients admitted to Renhe Hospital of China Three Gorges University from July 2014 to July 2015 were divided into two groups. The observation group (n = 57) In the control group (n = 56), only levamlodipine was given to the treatment group. One month after treatment, HAMA and HAMD scores were used to evaluate the improvement of the main symptoms in both groups. Before and after treatment, the ovarian function indexes such as Luteinizing hormone (LH ), Follicle-stimulating hormone (FSH) and estrogen (E2), and compared the clinical efficacy of the two groups after treatment. Results: The levels of LH, FSH and E2 after treatment in both groups were significantly improved compared with before treatment, and the improvement rate in observation group was significantly better than that in control group (P <0.05). The scores of HAMA and HAMD after treatment in both groups were lower than those before treatment, and the reduction in observation group was significantly better than that in control group (P <0.05). The clinical efficacy of the observation group after treatment was better than that of the control group, the difference was statistically significant (P <0.05). Conclusion: L-amlodipine combined with comprehensive psychological intervention can significantly improve the patient’s negative emotions and improve the clinical treatment effect, which has a higher clinical value.