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本文主要讨论内皮素(ET)在肝硬变腹水产生中起到了什么作用,以及ET在手术治疗前后的动态改变和可能发生的病理影响。 资料和方法 一、临床资料:肝硬变患者50例(男42,女8),平均年龄47.8岁(26～73岁)均为失代偿期,合并门静脉高压,食管胃静脉曲张,无心脏病、高血压及肾功不全。近期无上消化道出血、感染等,21例并腹水(大量10例,中等量6例,少量5例)。其中8例内科治疗后腹水消退,肝功按child分级,A级16例,B级21例,C级13例。其中31例行脾切除+门静脉奇静脉断流术。选择30例(男17,女13)健康献血员作对照组,平均年龄35.1岁(20～44岁).
This article focuses on the role of endothelin (ET) in the development of cirrhosis ascites and the dynamic changes in ET before and after surgery and possible pathological effects. Materials and Methods First, the clinical data: 50 patients with liver cirrhosis (male 42, female 8), mean age 47.8 years (26-73 years) were decompensated, with portal hypertension, esophageal varices, no heart disease , High blood pressure and renal insufficiency. Recent upper gastrointestinal bleeding, infection, 21 cases and ascites (a large number of 10 cases, 6 cases of moderate, a small amount of 5 cases). Among them, 8 cases of ascites subsided after medical treatment, and liver function was classified according to child. There were 16 cases of A grade, 21 cases of B grade and 13 cases of C grade. 31 cases of splenectomy + portal vein azygos disconnection. Thirty (male 17, female 13) healthy blood donors were selected as the control group, with an average age of 35.1 years (20-44 years).