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胰岛素受体底物(IRS)是胰岛素受体、胰岛素样生长因子 1受体酪氨酸蛋白激酶的主要底物 [1]。IRS 2在糖尿病的发生和发展中起着一定作用,它调节胰岛β细胞数目及功能 [2]。IRS 2还是骨代谢的调节因子,在胰岛素、胰岛素样生长因子 1等骨代谢因子的信号传递中起重要作用,IRS 2
Insulin receptor substrate (IRS) is the insulin receptor, insulin-like growth factor 1 receptor tyrosine kinase main substrate [1]. IRS 2 plays a role in the development and progression of diabetes, which regulates islet β cell number and function [2]. IRS 2 is also a regulator of bone metabolism and plays an important role in the signaling of bone metabolism factors such as insulin and insulin-like growth factor 1. IRS 2