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目的:评价固定药物组合的疗效和耐受性:在舒张压≤85mmHg情况下,氨氯地平+依那普利组与氨氯地平组在高血压合并冠心病患者的应用比较。方法:双盲,随机研究,入选患者为舒张压在≥90和<110mmHg之间同时具有冠状动脉疾病。将患者随即分成两组,A组采取联合用药治疗,B组单用氨氯地平治疗,疗程12周。结果:在80名入选患者中,两组患者治疗前后的舒张压(DAP)和收缩压(SAP)下降有显著差异,(p<0.01);但是,组间比较没有统计学差异。在12周中,A组患者比B组患者下肢水肿发病率低。结论:联合用药与单用氨氯地平一样,对于高血压合并冠心病患者和心绞痛(SAH)I、II级的患者有效。另外,联合应用依那普利和氨氯地平可阻滞肾素血管紧张素系统的作用,减少下肢水肿的发生。
OBJECTIVES: To evaluate the efficacy and tolerability of the combination of fixed drugs: compared with amlodipine and amlodipine in patients with hypertension and coronary heart disease at diastolic blood pressure <85 mmHg. METHODS: A double-blind, randomized study of patients with diastolic blood pressure of ≥90 and <110 mmHg with coronary artery disease. The patients were then divided into two groups, A group to take combination therapy, B group with amlodipine alone, the course of 12 weeks. RESULTS: Among the 80 enrolled patients, there was a significant difference in the diastolic (DAP) and systolic (SAP) drop between the two groups before and after treatment (p <0.01); however, there was no statistical difference between the two groups. In 12 weeks, the incidence of lower extremity edema was lower in patients in group A than in patients in group B. Conclusions: Combination therapy, as with amlodipine alone, is effective in patients with hypertension and coronary heart disease (SAH) grade I and II. In addition, the combination of enalapril and amlodipine can block the role of the renin-angiotensin system to reduce the occurrence of lower extremity edema.