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近几年来，有关各型原发性开角型青光眼疾病基因定位的研究取得一定进展。青少年型开角型青光眼疾病基因（ＧＬＣＩＡ基因）定位于第１号染色体１ｑ２２－ｑ２５区域ａｆｍ１２６ｙｄ８和ＡＴ３之间。成人型原发性开角型青光眼疾病候选基因有多个：（１）ＧＬＣＩＢ基因，可能来自于不同染色体上的突变；（２）ＧＬ－ＣＩＣ基因，位于第３号染色体３ｑ２１－ｑ２４区域Ｄ３Ｓ３６３７和Ｄ３Ｓ１７４４之间；（３）第６号染色体６ｐ２５区域Ｄ６Ｓ１６００和Ｄ６Ｓ２９６之间，并有多种表型；（４）第２号染色体Ｄ２Ｓ２１６１及Ｄ２Ｓ１７６之间。婴幼儿型青光眼疾病候选基因有：（１）ＧＬＣ３Ａ基因，位于第２号染色体２ｐ２１区域Ｄ２Ｓ１３２５和Ｄ２Ｓ１３５６之间；（２）ＧＬＣ３Ｂ基因，位于第１号染色体１ｐ３６区域Ｄ１Ｓ２２８和Ｄ１Ｓ５０７之间
In recent years, various types of primary open-angle glaucoma disease gene positioning research made some progress. The juvenile open-angle glaucoma disease gene (GLCIA gene) is located between afm126yd8 and AT3 on chromosome 1qq-q25 region. There are multiple candidate genes for adult primary open-angle glaucoma disease: (1) the GLCIB gene, which may be derived from mutations on different chromosomes; (2) the GL-CIC gene, located on chromosome D321, D3S1744; (3) Between chromosome 6p25 on chromosome 6 and D6S166 between D6S166 and has multiple phenotypes; (4) Between chromosome D2S2161 and D2S176. Candidate genes for infantile glaucoma disease are: (1) GLC3A gene located between D2S1325 and D2S1356 on chromosome 2p21 of chromosome 2; (2) GLC3B gene located between D1S228 and D1S507 on chromosome 1 p36 of chromosome 1