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目的 探讨脑胶质细胞增生症中增殖细胞核抗原 (PCNA)的表达及其与病理、预后之间的关系。方法对 3 4例脑胶质细胞增生症进行病理分级、分型 ;采用免疫组织化学方法研究PCNA在各级、各型脑胶质细胞增生症中的表达并进行统计学分析。结果 正常脑组织细胞PCNA阴性 ,3 4例脑胶质细胞增生症PCNA阳性表达不一 ,轻度胶质细胞增生症阳性率为 12 .4 6% ,中度为 2 9.89% ,重度为 5 0 .4 1% (各组间比较P <0 .0 1) ;小胶质细胞增生型PCNA阳性率为 16.4 2 % ,少突胶质细胞增生型为 3 4.61% ,星形细胞增生型为 4 7.5 2 % ,混合型为 3 1.2 2 %(各组间经方差分析P <0 .0 1)。结论 PCNA在不同级别和不同类型的脑胶质细胞增生症有不同程度的表达 ,可作为判断脑胶质细胞增生症增殖和预后的指标
Objective To investigate the expression of proliferating cell nuclear antigen (PCNA) in gliomatosis and its relationship with pathology and prognosis. Methods Thirty-four cases of glial cell hyperplasia were pathologically graded and classified. The expression of PCNA in various grades and types of glial cell hyperplasia was studied by immunohistochemistry and statistical analysis was performed. Results The PCNA expression in normal brain tissue was negative. The positive expression of PCNA in 34 cases of glial cell hyperplasia was different. The positive rate of mild glial cell hyperplasia was 12.66%, moderate 9.89% and severe 50% .4 1% (P <0.01 for each group); the positive rate of microglial proliferating PCNA was 16.4 2%, the percentage of oligodendrocyte proliferating was 3. 4.61%, and the percentage of astrocytosis was 4 7.5 2%, and mixed type 3 1.2 2% (ANOVA P <0.01). Conclusions PCNA is expressed in different degrees and different types of glial cell hyperplasia, which can be used as an indicator of proliferation and prognosis of gliomatosis