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目的探讨99mTc-奥曲肽眼眶显像在判断甲状腺相关性眼病(TAO)活动性中的作用。方法 81例TAO患者(151个眼眶)和10例正常对照者(20个眼眶)均行99mTc-奥曲肽眼眶显像,并采用勾画感兴趣区技术计算眼眶与枕部颅骨的奥曲肽摄取比值(O/OCC)。结果 TAO活动组O/OCC比值(1.78±0.44)显著高于TAO非活动组(1.06±0.17)及正常对照组(1.09±0.09),P均<0.001,而TAO非活动组O/OCC比值(1.06±0.17)与正常对照组(1.09±0.09)比较无显著性差异(P>0.05)。所有TAO患者的O/OCC比值与其CAS评分具有很好的相关性(γ=0.899,P<0.001),根据O/OCC比值绘制ROC曲线,曲线下面积为0.979,当O/OCC比值取1.34时,显像敏感性88.3%,特异性94.6%。结论 99mTc-奥曲肽眼眶显像可帮助客观判断TAO的活动性,为临床治疗方案的选择提供依据。
Objective To investigate the role of 99mTc-octreotide orbital imaging in judging the activity of thyroid-associated ophthalmopathy (TAO). Methods Eighty-one patients with TAO (151 eyes) and 10 normal controls (20 eyes) underwent 99mTc-octreotide orbital imaging. The ocular and occipital skull OCT (O / OCC). Results The O / OCC ratio (1.78 ± 0.44) in TAO active group was significantly higher than that in TAO inactive group (1.06 ± 0.17) and normal control group (1.09 ± 0.09), P <0.001, while the TAO inactive O / OCC ratio 1.06 ± 0.17) and normal control group (1.09 ± 0.09) no significant difference (P> 0.05). All patients with TAO had a good correlation with their CAS scores (γ = 0.899, P <0.001). The ROC curve was plotted against the O / OCC ratio. The area under the curve was 0.979. When the O / OCC ratio was 1.34 , Imaging sensitivity 88.3%, specificity 94.6%. Conclusion 99mTc-octreotide orbital imaging can help to objectively determine the activity of TAO and provide a basis for clinical treatment options.