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1例20岁女性为乌发自行服用何首乌粉15g/d。2周后,患者出现纳差及乏力;3周后出现尿色加深,肝功能检查示天冬氨酸转氨酶(AST)878 U/L,丙氨酸转氨酶(ALT)1121 U/L,总胆红素(TBil)100.8μmol/L,直接胆红素(DBil T)77.4μmol/L。服用何首乌粉第42天,实验室检查:AST472 U/L,ALT 755 U/L,TBil 102.9μmol/L,DBil 76.7μmol/L;白细胞计数3.2×10~9/L,中性粒细胞计数0.27×10~9/L。考虑药物引起肝损害和中性粒细胞缺乏可能性大。停用何首乌,给予保肝、退黄等综合治疗。治疗10 d后实验室检查:ALT 62 U/L,AST 73 U/L,DBil 20.5μmol/L,TBil 30.2μmol/L;白细胞计数6.2×10~9/L,中性粒细胞计数3.60×10~9/L。
A 20-year-old female UFA own take Polygonum powder 15g / d. After 2 weeks, the patient developed anorexia and fatigue; after 3 weeks, the urine color deepened. The liver function test showed aspartate aminotransferase (AST) 878 U / L, ALT 1121 U / L, 100.8 μmol / L TBil and 77.4 μmol / L DBil T. On the 42nd day of taking Radix Polygoni Multiflori powder, the laboratory tests showed that AST472U / L, ALT 755U / L, TBil 102.9μmol / L and DBil 76.7μmol / L; leukocyte count 3.2 × 10-9 / L, neutrophil count 0.27 × 10 ~ 9 / L. Consider the possibility of drug-induced liver damage and neutropenia. Polygonum discontinue, give liver protection, yellow and other comprehensive treatment. After 10 days of treatment, the laboratory tests were as follows: ALT 62 U / L, AST 73 U / L, DBil 20.5 μmol / L and TBil 30.2 μmol / L; leukocyte count 6.2 × 10 9 / L, neutrophil count 3.60 × 10 ~ 9 / L.