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目的:调查围手术期预防性使用抗菌药物的合理性,以提高合理用药水平。方法:对我院2006年3月948例住院手术患者围手术期抗菌药物预防性使用进行回顾性调查分析。结果:948例患者在抗菌药物1841次的预防性使用中,合理1039次(56.44%);基本合理189次(10.27%);不合理613次(33.29%)。不合理用药的主要表现形式为:用药时间过长,给药时间不当,剂量过大,选药不正确,非适宜指证,给药次数过少等。结论:围手术期预防性使用抗菌药物过程中存在某些不合理用药的情况。为此,应加强贯彻实施《抗菌药物临床应用指导原则》,以避免抗菌药物的不适宜应用。
Objective: To investigate the rationality of perioperative prophylactic use of antimicrobial agents in order to improve the rational use of drugs. Methods: A retrospective analysis of the prophylactic use of perioperative antibiotics in 948 hospitalized patients in our hospital in March 2006 was conducted. Results: A total of 948 patients took 1039 antibiotics (56.44%) prophylactically for 1841 preventive applications; 189 were reasonable (10.27%) and 613 (33.29%) were unreasonable. The main manifestations of irrational drug use are: medication time is too long, improper dosing time, overdose, drug selection is not correct, non-appropriate certification, administration frequency is too small. Conclusion: There are some irrational use of drugs in the prophylactic use of antibiotics during perioperative period. To this end, we should strengthen the implementation of “guidelines for clinical use of antimicrobial agents,” in order to avoid the inappropriate use of antimicrobial agents.