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目的研究局部应用愈疡液对溃疡性结肠炎的治疗作用。方法给ＳＤ大鼠经肛门注入８％乙酸，使之形成溃疡性结肠炎。大鼠随机分成４组，每组２０只。分别予常量愈疡液、高剂量愈疡液、水杨酸偶氮磺胺吡啶（ＳＡＳＰ）、生理盐水（ＮＳ）治疗，观察疗效。同时设正常对照组２０只，观察愈疡液对肝功能有无影响。结果经常量愈疡液治疗的模型动物，病情明显改善，疗效较应用ＳＡＳＰ及高剂量愈疡液治疗组疗效更佳，且愈疡液局部应用对肝功能无明显影响。结论常量愈疡液灌肠对实验性溃疡性结肠炎疗效显著，且对肝功能无明显影响。
Objective To study the effect of topical application of Yuyangye on ulcerative colitis. Methods SD rats were injected anal 8% acetic acid to form ulcerative colitis. Rats were randomly divided into 4 groups of 20 in each group. Were treated with Changyu Yuyangye, high-dosage Yuyangye, sulfamethazine salicylate (SASP) and normal saline (NS), and observed the curative effect. At the same time, 20 normal control groups were set up to observe whether Yuyangye had any effect on liver function. As a result, the model animals treated with Yuyangye regularly improved the condition significantly, and the curative effect was better than those treated with SASP and high-dose Yuyangye. The topical application of Yuyangye had no significant effect on liver function. Conclusion Changyu Yuyangye enema has significant curative effect on experimental ulcerative colitis, and has no significant effect on liver function.