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目的:探讨老年女性慢性丙型肝炎患者干扰素治疗前后血清甲状腺激素水平的变化。方法:检测13例老年女性慢性丙型肝炎患者在干扰素治疗不同时间甲状腺激素水平,并与26例中青年丙型肝炎患者、15例老年男性患者和20例同期正常体检者作对照研究。结果:在干扰素治疗12周时,老年女性组与各对照组比较,TSH升高,T3、T4、FT3、FT4明显低于治疗前水平(P<0.05)。结论:干扰素治疗可导致甲状腺激素代谢紊乱,在老年女性患者更容易出现甲状腺功能减退。
Objective: To investigate the changes of serum thyroid hormone levels in elderly women with chronic hepatitis C before and after interferon treatment. Methods Thirteen elderly women with chronic hepatitis C were treated with interferon for thyroid hormone at different time points. The control group was compared with 26 middle-aged and young hepatitis C patients, 15 elderly male patients and 20 normal controls. Results: At the 12th week of interferon treatment, TSH increased and T3, T4, FT3 and FT4 in elderly women were significantly lower than those before treatment (P <0.05). Conclusion: Interferon therapy can lead to disorders of thyroid hormone metabolism, and hypothyroidism is more likely to occur in elderly women.