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目的:回顾性分析胰肾联合移植术后围手术期外科并发症的发生、治疗及预后。方法:纳入2016年1月至2020年1月天津市第一中心医院的138例胰肾联合移植受者。回顾性分析围手术期外科并发症的种类、发生率、治疗及再手术情况，探讨并发症的发生原因及其对受者和移植物存活的影响。结果:138例胰肾联合移植受者，按是否发生外科并发症分为并发症组(35例)和无并发症组(103例)。围手术期外科并发症包括：移植胰腺静脉血栓1例(0.72%)，移植肾动脉血栓1例(0.72%)，消化道出血14例(10.14%)，腹腔出血3例(2.17%)，移植肾劈裂1例(0.72%)，肠漏2例(1.45%)，胰漏1例(0.72%)，尿漏2例(1.45%)，腹腔感染4例(2.90%)，完全性肠梗阻9例(6.52%，其中机械性肠梗阻1例)。并发症组受者、移植胰腺、移植肾的4年存活率分别为96.3%、88.9%、82.1%，无并发症组受者、移植胰腺、移植肾的4年存活率分别为100%、100%、98.8%。两组移植肾及胰腺的存活率差异有统计学意义(n P＝0.0 005和0.0 018)。n 结论:阿加曲班和/或低分子肝素抗凝、黏膜下止血、消化道内镜及肠梗阻导管的应用，可有效预防或治疗外科并发症，有助于改善受者及移植物预后。“,”Objective:To retrospectively explore the incidence, treatment and prognosis of perioperative surgical complications after simultaneous pancreas kidney(SPK)transplantation.Methods:A total of 138 cases of SPK transplantation from January 2016 to January 2020 were reviewed. Clinical types, incidence, treatment and reoperation of perioperative surgical complications were analyzed and the causes of complications discussed. The impact of surgical complications on recipients and graft survival was analyzed.Results:During perioperative period, surgical complications included pancreatic vein thrombosis(1 case, 0.72%), renal artery thrombosis(1 case, 0.72%), gastrointestinal bleeding(14 cases, 10.14%), abdominal hemorrhage(3 cases, 2.17%), renal split(1 case, 0.72%), intestinal leakage(2 cases, 1.45%), pancreatic leakage(1 case, 0.72%), urinary leakage(2 cases, 1.45%), abdominal infection(4 cases, 2.90%)and intestinal obstruction(9 cases, 6.52%). There was one case of mechanical ileus. The 4-year survival rates of patients with surgical complications, pancreas transplantation and kidney transplantation were 96.3%, 88.9% and 82.1% respectively. The 4-year survival rates of those without surgical complications, pancreas transplantation and kidney transplantation were 100%, 100% and 98.8% respectively. The survival rate of kidney and pancreas graft were significantly different between two groups(n P=0.0005, 0.0018).n Conclusions:Application of argatroban and/or low-molecular-weight heparin anticoagulation, submucosal hemostasis, gastrointestinal endoscopy and intestinal obstruction catheter can effectively prevent surgical complications and improve the survival of recipients and grafts.