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目的研究胃癌相关抗原MG7Ag在胃癌中的表达及其意义。方法采用流式细胞仪检测143例胃癌组织中MG7Ag的表达,同时随机选取30例慢性浅表性胃炎,30例慢性萎缩性胃炎,作为对照研究。结果MG7Ag阳性表达在胃癌、慢性浅表性胃炎、慢性萎缩性胃炎中分别为91.3%、14.9%、30.0%。胃癌MG7Ag阳性表达与胃癌有无淋巴结转移无相关性(P>0.05),胃癌MG7Ag阳性表达与胃癌分化程度亦无相关性(P>0.05)。结论从慢性浅表性胃炎→慢性萎缩性胃炎→胃癌,MG7Ag阳性表达率显著递增,与胃癌的浸润转移无明显相关性,MG7Ag有望成为临床上诊断胃癌可靠的肿瘤标记物。
Objective To study the expression of gastric cancer associated antigen MG7Ag in gastric cancer and its significance. Methods Flow cytometry was used to detect the expression of MG7Ag in 143 gastric cancer tissues. 30 cases of chronic superficial gastritis and 30 cases of chronic atrophic gastritis were randomly selected as the control study. Results The positive expression rates of MG7Ag in gastric cancer, chronic superficial gastritis and chronic atrophic gastritis were 91.3%, 14.9% and 30.0% respectively. The positive expression of MG7Ag in gastric cancer had no correlation with lymph node metastasis (P> 0.05). There was no correlation between the positive expression of MG7Ag in gastric cancer and the differentiation of gastric cancer (P> 0.05). Conclusions The positive rate of MG7Ag expression in chronic superficial gastritis → chronic atrophic gastritis → gastric cancer is significantly increased, which is not significantly correlated with the infiltration and metastasis of gastric cancer. MG7Ag is expected to become a reliable tumor marker for clinical diagnosis of gastric cancer.