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晚期慢性阻塞性肺疾病(COPD)患者由于低氧血症常引起肺动脉高压,1年内死亡率约为30%.随机对照研究表明,长期氧疗(LTOT)是提高此类患者生存率的有效措施.每日18小时,持续6个月的氧疗,可使平均肺动脉压和肺血管阻力(PVR)明显降低,但有些重症患者对LTOT 无反应.在以往的研究中,作者给重度COPD 患者口服钙拮抗剂Felo-dipine,发现其PVR 降低.本实验给正进行LTOT(16h·d~(-1)以上)并患COPD 和肺动脉高压的8例患者注入Felodipine,以探讨其对中央血液动力学和肺通气-灌注比例((?)_A/(?))的影响.
Patients with advanced chronic obstructive pulmonary disease (COPD) often cause pulmonary hypertension due to hypoxemia, with a 1-year mortality rate of about 30% .Studies of randomized controlled trials indicate that long-term oxygen therapy (LTOT) is an effective measure to improve the survival rate of these patients Oxygen therapy lasting 18 hours a day for 6 months significantly reduced mean pulmonary artery pressure and pulmonary vascular resistance (PVR), but some critically ill patients did not respond to LTOT In previous studies, the authors orally administered orally to patients with severe COPD The calcium antagonist Felo-dipine was found to have a decreased PVR.In this study, 8 patients with LTD (over 16h · d -1) and COPD and pulmonary hypertension were injected with Felodipine to investigate their effects on central hemodynamics And lung ventilation - perfusion ratio ((?) _ A / (?)).