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目的:了解苯那普利时充血性心力衰竭患者血清地高辛浓度及心功能的影响。方法:22例慢性充血性心力衰竭患者接受观察,服用地高辛0.25mg,每日1次,7天后待血清地高辛浓度(SDC)达稳态后加用苯那普利(洛汀新)10mg,每日1次,分别于联用后7天、14天抽血检测SDC、肌酐清除率、血清电解质变化,并评估心功能。结果:联用14天后SDC稍有下降,P<0.05,其它检测指标无明显变化,心功能有明显好转,P<0.05。
OBJECTIVE: To investigate the effect of serum digoxin concentration and cardiac function in patients with congestive heart failure during benazepril treatment. Methods: Twenty-two patients with chronic congestive heart failure were enrolled and treated with digoxin 0.25 mg once daily for 7 days until serum SD was steady-state followed by benazepril ) 10mg once daily. Blood samples were collected for SDC, creatinine clearance and serum electrolyte changes on the 7th day and 14th day after the combination. The cardiac function was evaluated. Results: SDC decreased slightly after 14 days of combination, P <0.05, no significant change of other test indexes, and significant improvement of cardiac function (P <0.05).