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本文研究了用Ｈｇｃｌ２染毒大鼠肝，肾线粒体氢过氧化物灭活酶活性，并对职业性汞中毒患者血液酶活性进行了检测。结果表明，与对照组比较，染毒组大鼠肾线粒体ＧＳＨ－ｐｘ活性和ＧＳＨ－Ｐｘ／ＧＲ比值均减少（Ｐ＜０．０５），而ＣＡＴ、ＧＲ和肝线粒体的相应酶活性则不受影响。此外，汞中毒患者血液中ＧＳＨ－Ｐｘ活性明显低于正常对照组（Ｐ＜０．０１），ＣＡＴ活性改变不显著，与动物实验结果极为一致。研究结果提示，汞诱发的肾毒性作用可能与ＧＳＨ－Ｐｘ抑制有关，推测氢过氧化物清除障碍可能是汞毒性作用的促进因素。
In this paper, mitochondrial hydroperoxide-inactivating enzyme activity in liver and kidney of rats exposed to Hgcl2 was studied, and blood enzyme activity in patients with occupational mercury poisoning was tested. The results showed that compared with the control group, the mitochondrial GSH-px activity and GSH-Px / GR ratio were decreased (P <0.05), while the corresponding enzymatic activities of CAT, GR and liver mitochondria were not affected influences. In addition, the activity of GSH-Px in the blood of patients with mercury poisoning was significantly lower than that of the normal control group (P <0.01), and CAT activity was not significantly changed, which was in good agreement with the animal experiments. The results suggest that mercury-induced nephrotoxicity may be related to GSH-Px inhibition, presumably hydroperoxide removal disorders may be the role of mercury to promote toxic effects.