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作者以往的研究指出大鼠慢性 GS_2中毒可引起脂类代谢紊乱,出现血清胆固醇的增加和主动脉壁中胆固醇稍有增高。由于提高了脂蛋自从血清向主动脉壁的渗入速率和主动脉壁胆固醇合成速度,从而导致主动脉壁内胆固醇的蓄积乃至发展成动脉粥样硬化。本文试评价大鼠接触 GS_2后上述两过程是否有所变化和中毒动物主动脉壁形态学损害与生化改变的关系。雌性大鼠,中毒组接触 GS_2浓度为1mg/l每天五小时,每周六天,共6～8个月,并设有对照组。实验第八个月对中毒和对照动物分
Previous studies by the authors indicate that chronic GS 2 poisoning in rats can cause lipid metabolism disorders with increased serum cholesterol and a slight increase in cholesterol in the aortic wall. Due to increased lipoprotein penetration rate from the serum to the aortic wall and the synthesis rate of cholesterol in the aortic wall, the accumulation of cholesterol in the aortic wall and even the formation of atherosclerosis. In this paper, we evaluated whether there was any change in these two processes after exposure to GS 2 and the relationship between morphological damage and biochemical changes in the aortic wall of the poisoned animals. Female rats, poisoning group exposure to GS 2 concentration of 1mg / l five hours a day, six days a week, a total of 6 to 8 months, and with the control group. In the eighth month of the experiment, poisoning and control animals were divided