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目的观察新三联联用灭 Hp 胶囊对消化性溃疡疗效及溃疡愈合质量的影响.方法采用随机双盲对照研究,75例活动期消化性溃疡并 Hp阳性患者随机服用①新三联:兰索拉唑+克拉霉素+阿莫西林;②“灭 Hp 胶囊”四联:新三联,连用10 d+灭 Hp 胶囊,连用28d;③安慰剂:胃舒平,连用28 d.疗程结束后4 wk 复查内镜,观察 Hp 根治和溃疡愈合情况,并评价再生粘膜组织学成熟度.结果新三联和“灭 Hp 胶囊”四联组溃疡愈合率和 Hp 根治率分别为88%,92%和100%,96%,(P>0.05),但其再生粘膜成熟度后者(优占89%)优于前者(优占41%)(P<.05);两组均明显优于安慰剂组溃疡愈合率(20%,P<0.05),Hp 根治率(0.0%,均 P<0.01)和再生粘膜组织成熟度(以差者为主占67%,分别 P<0.05,P<0.01).结论灭 Hp 胶囊四联疗法不但获得理想的 Hp 根治率和溃疡愈合率,更有显著提高溃疡愈合质量作用;为中西医结合治疗消化性溃疡开辟了新途径.
Objective To observe the effect of neo-triple combined with Hp capsule on the curative effect of peptic ulcer and the quality of ulcer healing.Methods A randomized, double-blind controlled study was conducted in 75 patients with active peptic ulcer and Hp positive patients treated with neo-triple: lansoprazole + Clarithromycin + amoxicillin; ② “Hp capsule” quadruple: the new triple, with 10 d + off Hp capsules, once every 28 days; ③ placebo: stomach Shuping, once every 28 d. 4 wk after the end of treatment review And the histological maturation of regenerative mucosa was evaluated.Results The healing rate of ulcer and the cure rate of Hp were 88%, 92% and 100% respectively in the new triple combined with “Hp capsule” , 96% (P> 0.05), but the latter (89%) was better than the former (41%) (P <.05), and the two groups were significantly better than the placebo group The cure rate (20%, P <0.05), the cure rate of Hp (0.0%, all P <0.01) and the degree of maturation of regenerative mucosa (accounting for 67% of the poor, P <0.05, P <0.01, respectively) Off Hp capsule quadruple therapy not only to achieve the desired rate of radical Hp and ulcer healing, but also significantly improve the quality of ulcer healing; for the treatment of peptic ulcer with traditional Chinese and Western medicine opened up a new way.