论文部分内容阅读
目的通过调查新疆和田地区维吾尔族自然长寿老人的流行病学特征,对影响自然长寿老人肾小球滤过率GFR的相关因素进行研究。方法应用WHO MONICA方案,分层随机抽取≥90岁的177名(男性107人,女性为70人)新疆和田地区自然长寿人群(自然长寿组)及随机抽取的197名和田地区于田县60~90岁维吾尔族老年人(老年组)进行问卷调查、体格检查和血尿检测等。结果经独立样本t检验:两组比较TG、TC、HDL-C、LDL-C、Apo-A、Apo-B、LP(a)、血肌酐CRE、血尿酸UA、腰围、平均收缩压差异均有统计学意义(P<0.05),自然长寿组高于老年组;平均舒张压比较,老年组高于长寿组(P<0.05)。非条件二分类Logistic回归分析示:年龄(OR=5.528)、尿酸UA(OR=1.006)是自然长寿老人肾功能损害的危险因素,高密度脂蛋白HDL-C(OR=0.243)是保护因素。结论和田自然长寿老人肾损害患病率处于相对较高水平,重视早期预防,采取相应干预措施,为延缓肾功能减退提供帮助。
Objective To investigate the epidemiological characteristics of Uygur natural longevity elderly people in Hetian, Xinjiang, and to study the related factors that affect the GFR of glomerular filtration rate in elderly with longevity. Methods A total of 177 subjects (107 males and 70 females) aged 90 years or older in Hetian area were selected randomly from WHO MONICA regimen and randomly selected from 197 natural and longevity groups in Hetian, Yutian, 90-year-old Uighur elderly (elderly) questionnaire, physical examination and hematuria testing. Results Independent sample t test: TG, TC, HDL-C, LDL-C, Apo-A, Apo-B and LP (P <0.05), and the longevity group was higher than the elderly group. The average diastolic pressure was higher in the elderly group than in the longevity group (P <0.05). Logistic regression analysis showed that age (OR = 5.528), uric acid UA (OR = 1.006) were the risk factors of renal damage in long-term longevity. High density lipoprotein HDL-C (OR = 0.243) was the protective factor. Conclusion The prevalence of renal damage in Wada natural longevity elderly is at a relatively high level, with emphasis on early prevention and appropriate interventions to delay renal impairment.