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目的探讨性别对rt-PA静脉溶栓治疗急性缺血性脑卒中患者疗效的影响。方法本研究采用回顾性病例对照研究。从2009年2月到2012年9月连续收集发病4.5 h内rt-PA静脉溶栓治疗的急性缺血性脑卒中患者作为研究对象。根据性别的不同将符合入选标准的病例分为2组:(1)女性组:该组由39例发病4.5 h内rt-PA静脉溶栓治疗的女性急性缺血性脑卒中患者组成;(2)男性组,该组由42例发病4.5 h内rt-PA静脉溶栓治疗的男性急性缺血性脑卒中患者组成。采用改良的Rankin量表评价神经功能恢复状况。结果 2组在90d内溶栓预后良好率(61.54%和52.38%,P=0.406)、颅内出血的发生率(7.69%和9.52%,P=0.769)、症状性颅内出血的发生率(5.13%和7.14%,P=0.707)及死亡率(5.13%和7.14%,P=0.707),差异无统计学意义。结论女性组与男性组相比,在静脉溶栓后90 d预后良好率及90 d内颅内出血、症状性颅内出血、死亡发生率差异无统计学意义(P>0.05),性别对急性缺血性脑卒中患者静脉溶栓疗效无影响。
Objective To investigate the effect of gender on the curative effect of rt-PA intravenous thrombolysis in patients with acute ischemic stroke. Methods This study used a retrospective case-control study. Acute ischemic stroke patients receiving rt-PA intravenous thrombolysis within 4.5 hours of onset from February 2009 to September 2012 were recruited as subjects. According to gender differences in the inclusion criteria will be divided into two groups: (1) female group: the group of 39 patients with onset of 4.5 h rt-PA intravenous thrombolytic therapy in women with acute ischemic stroke composition; (2 ) Male group, which consisted of 42 male acute ischemic stroke patients treated with 4.5 h rt-PA intravenous thrombolysis. A modified Rankin scale was used to assess neurological recovery. Results The rate of successful thrombolysis (61.54% and 52.38%, P = 0.406), the incidence of intracranial hemorrhage (7.69% and 9.52%, P = 0.769), the incidence of symptomatic intracranial hemorrhage (5.13% And 7.14% respectively, P = 0.707) and mortality (5.13% and 7.14%, P = 0.707). There was no significant difference between them. Conclusion There was no significant difference between the female group and the male group in the good prognosis at 90 days after intravenous thrombolysis and the incidence of intracranial hemorrhage, symptomatic intracranial hemorrhage and death within 90 days (P> 0.05) No effect on thrombolytic therapy in patients with stroke.