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1876年Malassez最早描述发生于细支气管肺泡上皮细胞的肺癌,称之肺髓样癌。肺内有多数小结节,呈慢性进展的肺炎型。以后报告逐渐增多。1953年Low通过电子显微镜证实肺泡细胞存在。关于肺泡细胞癌或细支气管癌多主张来源于细支气管癌的细支气管,其理由:①肺泡细胞尚未被确认;②慢性肺炎时包被肺泡那样增生的细胞源于细支气管基底细胞;③癌细胞类似于正常的支气管上皮细胞;④分化型癌,如癌细胞呈立方或圆柱状,在组织学上难以区别是肺癌或其他脏器转移性癌或在肺内进展型细支气管肺泡
In 1876 Malassez first described lung cancer that occurred in bronchioalveolar epithelial cells and called it medullary carcinoma of the lung. The majority of small nodules in the lungs showed a chronic progression of pneumonia. Later reports have gradually increased. Low in 1953 confirmed the presence of alveolar cells by electron microscopy. About alveolar cell carcinoma or bronchiolar carcinoma mostly advocates bronchioles originated from bronchiolar carcinoma, the reasons: 1 alveolar cells have not been confirmed; 2 chronic pneumonia when cells coated with alveolar hyperplasia arise from bronchial basal cells; 3 cancer cells Similar to normal bronchial epithelial cells; 4 differentiated cancers, such as cancer cells are cubic or cylindrical, histologically difficult to distinguish between lung cancer or metastatic carcinoma of other organs or in the lungs of the development of bronchioloalveolar