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目的观察高频热疗配合胸腔灌注化疗与单纯局部化疗治疗恶性胸水的近期疗效。方法将确诊为恶性胸水的患者随机分成治疗组(n=30)和对照组(n=35)。化疗方法采用温生理盐水100 ml+顺铂60 mg注入胸腔,每周灌注1次,连续灌注4周。治疗组灌注化疗后给予局部高频热疗2次/周、60 min/次。比较两组治疗效果。结果治疗组有效率(83.33%)高于对照组有效率(62.85%),差异有统计学意义(P<0.05),治疗组的生活质量改善率(86.67%)高于对照组(77.14%),差异有统计学意义(P<0.05)。结论采用胸腔灌注化疗联合局部高频热疗控制恶性胸水,疗效优于单纯胸腔化疗。
Objective To observe the short-term effect of high-frequency hyperthermia combined with pleural perfusion chemotherapy and simple local chemotherapy in the treatment of malignant pleural effusion. Methods Patients with malignant pleural effusion were randomly divided into treatment group (n = 30) and control group (n = 35). Chemotherapy with warm saline 100 ml + cisplatin 60 mg into the chest, perfusion weekly 1, continuous infusion for 4 weeks. The treatment group was given local hyperthermia after perfusion chemotherapy 2 times / week, 60 min / time. Compare the treatment effect of two groups. Results The effective rate of the treatment group (83.33%) was higher than that of the control group (62.85%), the difference was statistically significant (P <0.05). The improvement rate of the quality of life in the treatment group (86.67%) was higher than that of the control group , The difference was statistically significant (P <0.05). Conclusion Thoracic perfusion chemotherapy combined with local high frequency hyperthermia in the treatment of malignant pleural effusion is superior to simple thoracic chemotherapy.